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PNRC2

Domain

The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.

Function

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

Sequence Similarities

Belongs to the PNRC family. PNRC2 subfamily.

Tissue Specificity

Expressed in heart, lung, muscle and brain.

Cellular localization

Alternative names

HSPC208, PNRC2, Proline-rich nuclear receptor coactivator 2

swissprot:Q9NPJ4 omim:611882 entrezGene:55629 entrezGene:100505603