POGLUT2

Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001).

Protein modification; protein glycosylation.

N-glycosylated.

Belongs to the KDELC family.

• Endoplasmic reticulum lumen

EP58, KDELC1, UNQ1910/PRO4357, POGLUT2, Protein O-glucosyltransferase 2, Endoplasmic reticulum resident protein 58, KDEL motif-containing protein 1, Protein O-xylosyltransferase POGLUT2, ER protein 58, ERp58

• entrezGene:79070
• omim:611613
• swissprot:Q6UW63

Proteins

Immunology & Infectious Disease

58043Da