Expression is cell cycle-dependent, with highest levels in G2/M phase and lowest in G1.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites (PubMed:19074196, PubMed:24191025).
Colorectal cancer 10
CRCS10
A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome
MDPL
An autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, metabolic abnormalities including insulin resistance and diabetes mellitus, sclerodermatous skin, and a facial appearance characterized by mandibular hypoplasia. Sensorineural deafness occurs late in the first or second decades of life.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the DNA polymerase type-B family.
Widely expressed, with high levels of expression in heart and lung.
Proteins
Oncology
123631Da
We found 16 products in 2 categories
ab168827
ab264345
ab225907
ab132036
ab309788
Alexa Fluor® 488 Anti-DNA Polymerase delta, catalytic subunit antibody [EPR15118]
ab312118
Alexa Fluor® 555 Anti-DNA Polymerase delta, catalytic subunit antibody [EPR15118]
ab310588
Alexa Fluor® 594 Anti-DNA Polymerase delta, catalytic subunit antibody [EPR15118]
ab310157
Alexa Fluor® 647 Anti-DNA Polymerase delta, catalytic subunit antibody [EPR15118]