POLDIP2
Function
Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527).
Cellular localization
- Mitochondrion matrix
- Nucleus
- Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus.
Alternative names
PDIP38, POLD4, HSPC017, POLDIP2, Polymerase delta-interacting protein 2, 38 kDa DNA polymerase delta interaction protein, p38