POLDIP3

Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.

Phosphorylated at Ser-383 and Ser-385 by RPS6KB1.

• Nucleus
• Nucleus speckle
• Cytoplasm
• Nucleocytoplasmic shuttling protein.

KIAA1649, PDIP46, POLDIP3, Polymerase delta-interacting protein 3, 46 kDa DNA polymerase delta interaction protein, S6K1 Aly/REF-like target, p46, SKAR

• entrezGene:84271
• omim:611520
• swissprot:Q9BY77

Proteins

Immunology & Infectious Disease

46089Da