POLM
Function
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Sequence Similarities
Belongs to the DNA polymerase type-X family.
Tissue Specificity
Expressed in a number of tissues. Abundant in thymus.
Cellular localization
- Nucleus
Alternative names
polmu, POLM, DNA-directed DNA/RNA polymerase mu, Pol Mu, Terminal transferase