POLR1G
Function
Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation.
Isoform 2
Has been described as a component of preformed T-cell receptor (TCR) complex.
Post-translational modifications
Isoform 2
Undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other groups.
Isoform 1
Phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes.
Sequence Similarities
Belongs to the eukaryotic RPA34 RNA polymerase subunit family.
Cellular localization
- Nucleus
- Nucleolus
- Chromosome
- Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes.
Alternative names
ASE1, CAST, CD3EAP, PAF49, POLR1G, DNA-directed RNA polymerase I subunit RPA34, A34.5, Antisense to ERCC-1 protein, CD3-epsilon-associated protein, DNA-directed RNA polymerase I subunit G, RNA polymerase I-associated factor PAF49, ASE-1, CD3E-associated protein