Polypeptide N-acetylgalactosaminyltransferase 10

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.

Protein modification; protein glycosylation.

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues.

• Golgi apparatus membrane
• Single-pass type II membrane protein

Polypeptide N-acetylgalactosaminyltransferase 10, Polypeptide GalNAc transferase 10, Protein-UDP acetylgalactosaminyltransferase 10, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10, GalNAc-T10, pp-GaNTase 10, GALNT10

• entrezGene:55568
• omim:608043
• swissprot:Q86SR1

Proteins

Metabolism

68992Da