POM121
Domain
Contains F-X-F-G repeats.
Function
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).
Sequence Similarities
Belongs to the POM121 family.
Cellular localization
- Nucleus
- Nuclear pore complex
- Nucleus membrane
- Single-pass membrane protein
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.
Alternative names
KIAA0618, NUP121, POM121A, POM121, Nuclear envelope pore membrane protein POM 121, Nuclear envelope pore membrane protein POM 121A, Nucleoporin Nup121, Pore membrane protein of 121 kDa