POMC
Function
Corticotropin
Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha
Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta
Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin
Endogenous orexigenic opiate.
Met-enkephalin
Endogenous opiate.
Involvement in disease
Obesity
OBESITY
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
None
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Obesity, early-onset, with adrenal insufficiency and red hair
OBAIRH
An autosomal recessive disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
Sequence Similarities
Belongs to the POMC family.
Tissue Specificity
ACTH and MSH are produced by the pituitary gland.
Cellular localization
- Secreted
- Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.
Alternative names
Pro-opiomelanocortin, POMC, Corticotropin-lipotropin