Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
The signal sequence is not cleaved.
Belongs to the paraoxonase family.
Widely expressed with highest expression in liver, lung, placenta, testis and heart.
Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, Serum aryldialkylphosphatase 2, A-esterase 2, PON2
Proteins
Immunology & Infectious Disease
39381Da
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ab96553