PON2

Function

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Post-translational modifications

The signal sequence is not cleaved.

Sequence similarities

Belongs to the paraoxonase family.

Tissue specificity

Widely expressed with highest expression in liver, lung, placenta, testis and heart.

Cellular localization

• Membrane
• Peripheral membrane protein

Alternative names

• Serum paraoxonase/arylesterase 2
• PON 2
• Aromatic esterase 2
• Serum aryldialkylphosphatase 2
• A-esterase 2
• PON2

Database links

• entrezGene:5445
• omim:602447
• swissprot:Q15165

Target type

Proteins

Molecular weight

39381Da