PON2
Function
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Post-translational modifications
The signal sequence is not cleaved.
Sequence Similarities
Belongs to the paraoxonase family.
Tissue Specificity
Widely expressed with highest expression in liver, lung, placenta, testis and heart.
Cellular localization
- Membrane
- Peripheral membrane protein
Alternative names
Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, Serum aryldialkylphosphatase 2, A-esterase 2, PON2