Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
The signal sequence is not cleaved.
Belongs to the paraoxonase family.
Serum paraoxonase/lactonase 3, PON3
Proteins
Immunology & Infectious Disease
39607Da
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