Pon3
Function
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity).
Post-translational modifications
Glycosylated.
The signal sequence is not cleaved.
Sequence Similarities
Belongs to the paraoxonase family.
Cellular localization
- Secreted
- Extracellular space
Alternative names
Serum paraoxonase/lactonase 3, Pon3