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POPDC2

Function

Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.

Sequence similarities

Belongs to the popeye family.

Tissue specificity

Expressed predominantly in the heart and in the skeletal muscle.

Cellular localization

  • Membrane
  • Multi-pass membrane protein
  • Cell membrane
  • Sarcolemma

Alternative names

  • Popeye domain-containing protein 2
  • Popeye protein 2
  • POP2
  • POPDC2

Target type

Proteins

Molecular weight

40448Da