POR
GeneName
POR
Summary
POR, also known as PIB, porin, or Pcr, is a 77 kDa protein predominantly located in the endoplasmic reticulum membrane and other membrane-bound organelles. It functions primarily as a cytochrome-b5 reductase, facilitating electron transfer processes and playing a crucial role in various metabolic pathways, including fatty acid oxidation and nitric oxide metabolism. POR is involved in the binding and activation of enzymes, and it participates in the electron transport chain, impacting cellular responses to hormonal stimuli and regulating apoptotic processes.
Importance
POR is relevant to: - Metabolic disorders linked to fatty acid oxidation and carnitine metabolism due to its role in energy production. - Hormonal regulation and responses, particularly in the context of follicle-stimulating hormone and steroid hormone biosynthesis. - Nitric oxide metabolism, which is important in various physiological and pathological processes, including vascular function and inflammation. - Chondrocyte differentiation and growth plate cartilage proliferation, highlighting its potential implications in developmental biology and cartilage-related diseases.
Top Products
For researchers investigating the POR gene, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Cytochrome P450 Reductase antibody (ab13513), which has garnered 27 citations, highlighting its reliability in Western blotting (WB) and immunocytochemistry (ICC). Additionally, we offer the recombinant monoclonal antibody, Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597). This antibody has been validated in knockout models and is suitable for a broader range of applications, including WB, immunohistochemistry (IHC), ICC, and flow cytometry (FC). With 11 citations, it is gaining traction in the research community, making it a versatile choice for those requiring consistent and reliable detection of POR. The Anti-Cytochrome P450 Reductase antibody ELISA Kit (ab106255) is an excellent option for researchers looking to measure POR in their samples.
Abcam Product Citation Summary
The data indicates that the Abcam antibody ab13513 is utilised for detecting POR in human MCF-7 cells through western blotting. The studies focus on the effects of berberine, highlighting the relevance of POR in cancer research.
Abcam Product Citation Table
Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Involvement in disease
Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis
ABS1
A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures.
None
The disease is caused by variants affecting the gene represented in this entry.
Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency
DISPORD
A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the NADPH--cytochrome P450 reductase family.
In the N-terminal section; belongs to the flavodoxin family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Cytoplasmic side
Alternative names
CYPOR, POR, NADPH--cytochrome P450 reductase, CPR, P450R