POSTN
GeneName
POSTN
Summary
POSTN, also known as periostin, OSF-2, or osteoblast specific factor 2, is a 93kDa secreted protein that is primarily localised in the extracellular matrix and plays a vital role in cell adhesion and tissue development. It is expressed in various tissues, particularly in bone and connective tissues, and is involved in processes such as bone regeneration and extracellular matrix organisation. POSTN interacts with multiple cell types, influencing cellular responses to growth factors and cytokines, and is implicated in the regulation of the Notch signalling pathway and smooth muscle cell migration.
Importance
POSTN is relevant to: - Bone health and regeneration, making it a target for research in osteoporosis and fracture healing - Fibrosis and tissue repair due to its role in extracellular matrix organisation and cell adhesion - Cancer biology, as it may influence tumour progression and metastasis through its effects on cell migration - Cardiovascular research, given its involvement in the regulation of systemic arterial blood pressure and smooth muscle function
Top Products
For researchers investigating POSTN, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Periostin antibody (ab14041), which has garnered 264 citations, highlighting its reliability in the field. This antibody is particularly effective for immunohistochemistry (IHC) and immunocytochemistry (ICC), making it a versatile choice for various applications. Additionally, we offer the recombinant antibody, Anti-Periostin antibody [EPR20806] (ab215199), which is validated for IHC. With 22 citations, this monoclonal antibody provides the batch-to-batch consistency that researchers often seek in their experiments. Together, these antibodies provide robust options for studying POSTN with confidence. The Anti-Periostin antibody ELISA Kit (ab152099), supported by 6 citations, is an excellent option for researchers looking to measure POSTN levels in their samples.
Abcam Product Citation Summary
The data indicates that POSTN is being studied in various contexts, particularly in relation to human keloid tissue, cancer, and osteoarthritis, as well as in mouse models focusing on cardiac injury and development. The use of both immunohistochemistry and western blotting suggests a comprehensive approach to understanding POSTN's role in these biological processes.
Abcam Product Citation Table
Function
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
Post-translational modifications
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).
Tissue Specificity
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Expressed in the kidney (PubMed:21763681). Expressed in the lung (PubMed:22079858). Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
Cellular localization
- Golgi apparatus
- Secreted
- Secreted
- Extracellular space
- Extracellular matrix
- Colocalizes with BMP1 in the Golgi.
Alternative names
OSF2, POSTN, Periostin, PN, Osteoblast-specific factor 2, OSF-2