Postn
Developmental stage
In the heart, expressed from embryonic day 10.5. Continues to be strongly expressed throughout cardiac development and into adulthood (PubMed:11335131).
Function
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:10404027). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (PubMed:20181949).
Post-translational modifications
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; these residues may be required for binding to calcium (PubMed:18450759). According to a more recent report in human, does not contain vitamin K-dependent gamma-carboxyglutamate residues (By similarity).
Tissue Specificity
Preferentially expressed in periosteum and periodontal ligament (PubMed:10404027). Also expressed in the developing and adult heart (PubMed:11335131).
Cellular localization
- Golgi apparatus
- Secreted
- Secreted
- Extracellular space
- Extracellular matrix
- Colocalizes with BMP1 in the Golgi (PubMed:20181949).
Alternative names
Osf2, Postn, Periostin, PN, Osteoblast-specific factor 2, OSF-2