Pou1f1
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Function
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.
Sequence Similarities
Belongs to the POU transcription factor family. Class-1 subfamily.
Cellular localization
- Nucleus
Alternative names
Ghf-1, Pit-1, Pit1, Pou1f1, Pituitary-specific positive transcription factor 1, PIT-1, Growth hormone factor 1, GHF-1