Pou2f2
Developmental stage
Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation.
Function
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:1281152, PubMed:2011512). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.
Isoform OCT2.1
Activates octamer-containing promoters.
Isoform OCT2.2
Activates octamer-containing promoters.
Isoform OCT2.3
Activates octamer-containing promoters.
Isoform OCT2.4
Represses some promoters and activate others.
Isoform OCT2.5
Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity).
Isoform OCT2.7
Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels.
Sequence Similarities
Belongs to the POU transcription factor family. Class-2 subfamily.
Tissue Specificity
Highest in B cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes.
Isoform OCT2.1
Expressed at higher levels in B-cells than in neuronal cells.
Isoform OCT2.2
Expressed in neuronal cell lines and brain, but not dorsal root ganglia.
Isoform OCT2.3
Expressed at lower levels in neuronal cells than in B cells.
Isoform OCT2.4
Expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia.
Isoform OCT2.5
Widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B cells.
Isoform OCT2.6
Either absent in, or expressed at very low levels in neuronal cells and brain.
Isoform OCT2.7
Expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells.
Cellular localization
- Cytoplasm
- Nucleus
- In alveolus epithelial cells of mammary glands, present in the nucleus and cytoplasm. In HC11 mammary epithelial cells, present in the nucleus and preinuclear regions.
Alternative names
Oct2, Otf2, Pou2f2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding protein 2, Octamer-binding transcription factor 2, Oct-2, OTF-2