POU2F3
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971).
Sequence Similarities
Belongs to the POU transcription factor family. Class-2 subfamily.
Tissue Specificity
Specifically expressed in epidermis and cultured keratinocytes.
Cellular localization
- Nucleus
Alternative names
OTF11, PLA1, POU2F3, Octamer-binding protein 11, Octamer-binding transcription factor 11, Transcription factor PLA-1, Transcription factor Skn-1, Oct-11, OTF-11