POU6F1
Function
Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').
Sequence Similarities
Belongs to the POU transcription factor family. Class-6 subfamily.
Tissue Specificity
In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.
Cellular localization
- Nucleus
Alternative names
BRN5, MPOU, TCFB1, POU6F1, Brain-specific homeobox/POU domain protein 5, mPOU homeobox protein, Brain-5, Brn-5