PPAR alpha

Function

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Tissue specificity

Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758).

Cellular localization

• Nucleus

Alternative names

• Peroxisome proliferator-activated receptor alpha
• PPAR-alpha
• Nuclear receptor subfamily 1 group C member 1
• NR1C1
• PPARA
• PPAR

Database links

• entrezGene:5465
• omim:170998
• swissprot:Q07869

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

52225Da