PPARGC1B

Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Ubiquitous with higher expression in heart, brain and skeletal muscle.

• Nucleus

PERC, PGC1, PGC1B, PPARGC1, PPARGC1B, Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PGC-1-related estrogen receptor alpha coactivator

• entrezGene:10891
• entrezGene:133522
• omim:604517
• omim:608886
• swissprot:Q86YN6
• swissprot:Q9UBK2

Proteins

Immunology & Infectious Disease

113222Da