PPFIA1
Domain
The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
Function
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Sequence Similarities
Belongs to the liprin family. Liprin-alpha subfamily.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Cell cortex
- Cytoplasm
- Colocalizes with PTPRF near focal adhesions.
Alternative names
LIP1, PPFIA1, Liprin-alpha-1, LAR-interacting protein 1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, LIP-1, PTPRF-interacting protein alpha-1