PPFIA2

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165).

Belongs to the liprin family. Liprin-alpha subfamily.

Expressed only in brain.

• Cytoplasm
• Cell surface
• Cell projection
• Dendritic spine
• Colocalizes with PTPRF at the cell surface.

Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2, PPFIA2

• entrezGene:8499
• omim:603143
• swissprot:O75334
• swissprot:Q2M3G8

Proteins

Immunology & Infectious Disease

143291Da