PPFIA3
Domain
The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
Function
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Sequence Similarities
Belongs to the liprin family. Liprin-alpha subfamily.
Tissue Specificity
Predominantly expressed in brain (PubMed:9624153). Also detected in sperm (at protein level) (PubMed:23124857).
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Also detected in epididymosome.
Alternative names
KIAA0654, PPFIA3, Liprin-alpha-3, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3, PTPRF-interacting protein alpha-3