PPFIA4
Domain
The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS (By similarity).
Function
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).
Sequence Similarities
Belongs to the liprin family. Liprin-alpha subfamily.
Tissue Specificity
Expressed only in the heart, brain, and skeletal muscle.
Cellular localization
- Cytoplasm
- Cell surface
- Colocalizes with PTPRF at the cell surface.
Alternative names
KIAA0897, PPFIA4, Liprin-alpha-4, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4, PTPRF-interacting protein alpha-4