PPIH
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
Sequence Similarities
Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
Cellular localization
- Nucleus speckle
- Cytoplasm
- Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
Alternative names
CYP20, CYPH, PPIH, Peptidyl-prolyl cis-trans isomerase H, PPIase H, Rotamase H, Small nuclear ribonucleoprotein particle-specific cyclophilin H, U-snRNP-associated cyclophilin SnuCyp-20, CypH, USA-CYP