PPL
Developmental stage
Expressed in the epidermis, nuclei of dermal fibroblasts, cell periphery of flattened keratinocytes, and dermal and epithelial cells lining the excretory ducts of the sweat glands in neonatal foreskin.
Function
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Sequence Similarities
Belongs to the plakin or cytolinker family.
Tissue Specificity
Expressed in stratified squamous epithelia and in some other epithelia.
Cellular localization
- Cell junction
- Desmosome
- Cytoplasm
- Cytoskeleton
- Cell membrane
- Cytoplasm
Alternative names
KIAA0568, PPL, Periplakin, 190 kDa paraneoplastic pemphigus antigen, 195 kDa cornified envelope precursor protein