Expressed in the epidermis, nuclei of dermal fibroblasts, cell periphery of flattened keratinocytes, and dermal and epithelial cells lining the excretory ducts of the sweat glands in neonatal foreskin.
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Belongs to the plakin or cytolinker family.
Expressed in stratified squamous epithelia and in some other epithelia.
Proteins
204747Da
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ab72422