PPM1A
Function
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Post-translational modifications
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
Sequence Similarities
Belongs to the PP2C family.
Cellular localization
- Nucleus
- Cytoplasm
- Cytosol
- Membrane
- Lipid-anchor
- Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
Alternative names
PPPM1A, PPM1A, Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA, PP2C-alpha