PPM1B
Function
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Post-translational modifications
Isgylation negatively regulates its activity.
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
Sequence Similarities
Belongs to the PP2C family.
Tissue Specificity
Highly expressed in heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Cytosol
- Membrane
- Lipid-anchor
- Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
Alternative names
PP2CB, PPM1B, Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta