PPM1B

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Isgylation negatively regulates its activity.

N-myristoylation is essential for the recognition of its substrates for dephosphorylation.

Belongs to the PP2C family.

Highly expressed in heart and skeletal muscle.

• Cytoplasm
• Cytosol
• Membrane
• Lipid-anchor
• Weakly associates at the membrane and N-myristoylation mediates the membrane localization.

PP2CB, PPM1B, Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta

• entrezGene:5495
• omim:603770
• swissprot:O75688

Proteins

Metabolism

52643Da