PPM1E
Function
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).
Sequence Similarities
Belongs to the PP2C family.
Cellular localization
- Nucleus
- Cytoplasm
- A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus.
Alternative names
CAMKN, KIAA1072, POPX1, PPM1E, Protein phosphatase 1E, Ca(2+)/calmodulin-dependent protein kinase phosphatase N, CaMKP-nucleus, Partner of PIX 1, Partner of PIX-alpha, CaMKP-N, CaMKN, Partner of PIXA