PPM1F
Function
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
Involvement in disease
Defects in PPM1F may be a cause of sclerosing cholangitis, short stature, hypothyroidism, and abnormal tongue pigmentation.
Sequence Similarities
Belongs to the PP2C family.
Alternative names
KIAA0015, POPX2, PPM1F, Protein phosphatase 1F, Ca(2+)/calmodulin-dependent protein kinase phosphatase, Partner of PIX 2, Protein fem-2 homolog, CaM-kinase phosphatase, CaMKPase, hFem-2