PPME1
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
Post-translational modifications
Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
Sequence Similarities
Belongs to the AB hydrolase superfamily.
Alternative names
PME1, PP2593, PRO0750, PPME1, Protein phosphatase methylesterase 1, PME-1