PPP1R11
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Auto-ubiquitinated.
Tissue Specificity
Widely expressed.
Alternative names
HCGV, TCTE5, PPP1R11, E3 ubiquitin-protein ligase PPP1R11, Hemochromatosis candidate gene V protein, Protein phosphatase 1 regulatory subunit 11, Protein phosphatase inhibitor 3, HCG V