PPP1R13B
Domain
The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.
Function
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Sequence Similarities
Belongs to the ASPP family.
Tissue Specificity
Reduced expression in breast carcinomas expressing a wild-type TP53 protein.
Cellular localization
- Cytoplasm
- Nucleus
- Predominantly cytoplasmic. Some fraction is nuclear.
Alternative names
ASPP1, KIAA0771, PPP1R13B, Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B