PPP1R14A phospho T38
Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Sequence Similarities
Belongs to the PP1 inhibitor family.
Tissue Specificity
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Cellular localization
- Cytoplasm
Alternative names
CPI17, PPP1INL, PPP1R14A, Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, Protein kinase C-potentiated inhibitor protein of 17 kDa, CPI-17