Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Phosphorylated on serine residues.

Belongs to the phosphatase 2A regulatory subunit B56 family.

Widely expressed with the highest expression in heart and skeletal muscle.

• Cytoplasm
• Nucleus
• Chromosome
• Centromere
• From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PP2A B subunit isoform R5-alpha, PR61alpha, PPP2R5A

• entrezGene:5525
• omim:601643
• swissprot:Q15172

Proteins

Metabolism

56194Da