PPP2R5A
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Post-translational modifications
Phosphorylated on serine residues.
Sequence Similarities
Belongs to the phosphatase 2A regulatory subunit B56 family.
Tissue Specificity
Widely expressed with the highest expression in heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Nucleus
- Chromosome
- Centromere
- From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.
Alternative names
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PP2A B subunit isoform R5-alpha, PR61alpha, PPP2R5A