PPP3CC

The autoinhibitory domain prevents access to the catalytic site.

The autoinhibitory segment prevents access to the substrate binding site.

Possible isomerization of Pro-305 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.

Belongs to the PPP phosphatase family. PP-2B subfamily.

Testis.

• Mitochondrion
• Localizes in the mitochondria in a SPATA33-dependent manner.

CALNA3, CNA3, PPP3CC, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform

• entrezGene:5533
• omim:114107
• swissprot:P48454

Proteins

Neuroscience

58129Da