PPP6C

Function

Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation (PubMed:29053956).

Sequence similarities

Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.

Tissue specificity

Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.

Cellular localization

• Mitochondrion
• Cytoplasm

Alternative names

• Serine/threonine-protein phosphatase 6 catalytic subunit
• PP6C
• PPP6C
• PPP6

Database links

• entrezGene:5537
• omim:612725
• swissprot:O00743

Target type

Proteins

Molecular weight

35144Da