PPTC7
Function
Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:30267671). Positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (By similarity). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (By similarity). Alternatively, may promote SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (By similarity).
Sequence Similarities
Belongs to the PP2C family.
Tissue Specificity
Expressed in keratinocytes (at protein level).
Cellular localization
- Mitochondrion matrix
Alternative names
TAPP2C, PPTC7, Protein phosphatase PTC7 homolog, T-cell activation protein phosphatase 2C, T-cell activation protein phosphatase 2C-like, TA-PP2C