PPY
GeneName
PPY
Summary
PPY, also known as APP, PNP, or PPP, is a 10 kDa neuropeptide hormone that is primarily expressed in the cytoplasm and secreted into the extracellular space. It plays a significant role in neuropeptide signaling pathways and is involved in regulating feeding behaviour. PPY functions by binding to G protein-coupled receptors, particularly neuropeptide Y receptors, to mediate its effects on appetite and energy homeostasis. Its secretion is crucial for the modulation of various physiological processes.
Importance
PPY is relevant to: - The regulation of appetite and food intake, making it a target for obesity and metabolic disorder research - Understanding neuropeptide signaling mechanisms, which can provide insights into neurodegenerative diseases - The potential development of therapeutic strategies for conditions related to feeding behaviour and energy balance
Top Products
For researchers investigating PPY, we recommend two primary antibodies that cater to different experimental needs. The first is the well-cited polyclonal antibody, Anti-Pancreatic Polypeptide antibody (ab77192), which has garnered 24 citations and is particularly effective for immunohistochemistry (IHC) and flow cytometry (FC). This antibody is a trusted choice for those looking to study PPY in various biological contexts. Additionally, we offer the recombinant antibody, Anti-Nucleoside phosphorylase antibody [EPR5714] (ab109559), which has been validated in knockout models and is suitable for western blotting (WB). This product provides the batch-to-batch consistency that researchers often seek in their experiments. Together, these antibodies provide robust options for studying PPY across different applications. The Human PNP ELISA Kit (ab260069) is an excellent option for researchers looking to measure purine nucleoside phosphorylase levels in their samples.
Abcam Product Citation Summary
The data indicates that Abcam antibodies targeting pancreatic polypeptide (PPY) have been effectively used in immunofluorescence and immunohistochemistry applications across different species, including rats and humans. The studies focus on pancreatic islet cell cultures and pancreatic development, highlighting the relevance of PPY in these biological contexts.
Abcam Product Citation Table
Function
Pancreatic polypeptide
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
Sequence Similarities
Belongs to the NPY family.
Cellular localization
- Secreted
Alternative names
PNP, PPY, Pancreatic polypeptide prohormone, PH, Pancreatic polypeptide Y