PRAME

The protein expressed by gene PRAME functions as a transcriptional repressor, inhibiting retinoic acid signaling through retinoic acid receptors RARA, RARB, and RARG. It prevents retinoic acid-induced cell proliferation arrest, differentiation, and apoptosis. This supplementary information is collated from multiple sources and compiled automatically.

Protein modification; protein ubiquitination.

Belongs to the PRAME family.

Expressed in testis. Detected in samples of kidney, brain and skin.

• Nucleus
• Chromosome
• Cytoplasm
• Golgi apparatus
• Cell membrane
• Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923).

MAPE, OIP4, PRAME, Melanoma antigen preferentially expressed in tumors, Opa-interacting protein 4, Preferentially expressed antigen of melanoma, OIP-4

• entrezGene:23532
• omim:606021
• swissprot:P78395

Proteins

Oncology

57890Da