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PRAME
Function
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Sequence similarities
Belongs to the PRAME family.
Tissue specificity
Expressed in testis. Detected in samples of kidney, brain and skin.
Cellular localization
- Nucleus
- Cell membrane
Alternative names
- Melanoma antigen preferentially expressed in tumors
- Opa-interacting protein 4
- Preferentially expressed antigen of melanoma
- OIP-4
- PRAME
- OIP4
- MAPE
Database links
Target type
Proteins
Primary research area
Oncology
Molecular weight
57890Da