PRCP
Function
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Sequence Similarities
Belongs to the peptidase S28 family.
Tissue Specificity
Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
Cellular localization
- Lysosome
Alternative names
PCP, PRCP, Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase