Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026).
Sumoylation at Lys-847 by PIAS1 increases transcriptional repressor activity, and is critical for plasma cell differentiation (By similarity). Can be sumoylated with SUMO1 and SUMO2 by PML. Degradation of the wild-type protein mostly depends upon sumoylation, rather than ubiquitination (By similarity). Desumoylated by SENP1 and SENP6 (By similarity).
Ubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome.
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Expressed in bone marrow macrophages (at protein level) (PubMed:32741026). Expressed in innate lymphocytes, including tissue-resident conventional natural killer (cNK) cells in liver (PubMed:27102484). Expressed also weakly in tissue-resident natural killer (trNK) and natural killer T (NKT) cells in liver (PubMed:27102484).
Isoform 1
Expressed in bone marrow, spleen and lymph node but not in brain, heart, kidney, liver, ovary or muscle. Weak expression detected in the lung.
Isoform 3
Expressed only in the yolk sac.
Isoform 4
Expressed in embryo, yolk sac, placenta, splenocytes, and activated T-cells.
Blimp1, Prdm1, PR domain zinc finger protein 1, B lymphocyte-induced maturation protein 1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, Blimp-1
Proteins
Epigenetics
95836Da
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