PRDM15
Developmental stage
Expressed in fetal tissues.
Function
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).
Sequence Similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Tissue Specificity
Detected in all tissues examined.
Cellular localization
- Nucleus
Alternative names
C21orf83, ZNF298, PRDM15, PR domain zinc finger protein 15, PR domain-containing protein 15, Zinc finger protein 298