Peroxiredoxin 5

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

S-palmitoylated (PubMed:31740833). Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833).

Isoform Mitochondrial

S-palmitoylated (PubMed:31740833). Depalmitoylated by ABHD10 (PubMed:31740833).

Belongs to the peroxiredoxin family. Prx5 subfamily.

Widely expressed.

• Isoform Mitochondrial
• Mitochondrion
• Isoform Cytoplasmic+peroxisomal
• Cytoplasm
• Peroxisome matrix
• Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.

ACR1, SBBI10, PRDX5, Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, PLP, Peroxiredoxin V, Peroxisomal antioxidant enzyme, TPx type VI, Thioredoxin peroxidase PMP20, Thioredoxin-dependent peroxiredoxin 5, AOEB166, Prx-V

• entrezGene:25824
• omim:606583
• swissprot:P30044

Proteins

Metabolism

22086Da