PRDX5
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Post-translational modifications
S-palmitoylated (PubMed:31740833). Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833).
Isoform Mitochondrial
S-palmitoylated (PubMed:31740833). Depalmitoylated by ABHD10 (PubMed:31740833).
Sequence Similarities
Belongs to the peroxiredoxin family. Prx5 subfamily.
Tissue Specificity
Widely expressed.
Cellular localization
- Isoform Mitochondrial
- Mitochondrion
- Isoform Cytoplasmic+peroxisomal
- Cytoplasm
- Peroxisome matrix
- Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.
Alternative names
ACR1, SBBI10, PRDX5, Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, PLP, Peroxiredoxin V, Peroxisomal antioxidant enzyme, TPx type VI, Thioredoxin peroxidase PMP20, Thioredoxin-dependent peroxiredoxin 5, AOEB166, Prx-V