PREX1
Function
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Tissue Specificity
Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Cellular localization
- Cytoplasm
- Cytosol
- Cell membrane
- Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Alternative names
KIAA1415, PREX1, P-Rex1