PRG2
Developmental stage
Levels of the proform increase in serum and placenta during pregnancy.
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Post-translational modifications
Nitrated.
Tissue Specificity
Detected in plasma and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
Cellular localization
- Bone marrow proteoglycan
- Secreted
- The proform is secreted.
- Eosinophil granule major basic protein
- Cytoplasmic vesicle
- Secretory vesicle
- The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
Alternative names
MBP, PRG2, Bone marrow proteoglycan, BMPG, Proteoglycan 2