PRH1

Function

PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Post-translational modifications

Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.

A hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.

Cellular localization

• Secreted

Alternative names

PRH2, PRH1, Salivary acidic proline-rich phosphoprotein 1/2, Db-s, PRP-1/PRP-2, Parotid acidic protein, Parotid double-band protein, Parotid isoelectric focusing variant protein, Parotid proline-rich protein 1/2, Pr1/Pr2, Protein C, Pa, PIF-S

Database links

swissprot:P02810 omim:168730 omim:168790 entrezGene:5554 entrezGene:5555